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General supportive measures should be applied with particular attention to the maintenance of adequate urinary output

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Resistance (strength) training in elders reliably increases muscle mass and power, and aerobic training preserves aerobic fitness and mitochondrial enzymes

Also, a mouse model for late-onset mitochondrial myopathy due to overexpression of mutated Twinkle protein, a nuclear-encoded replicative helicase of mtDNA, showed clear health improvements after 10 months of KD

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